Human brain atlases consisting of MRI templates and semantic labels serve a critical role in neuroimaging, by mainly facilitating spatial normalization and automated segmentation for the purposes of voxel-wise, region of interest, and network analyses. Our lab has developed and released the IIT Human Brain Atlas for the adult brain, a comprehensive set of: anatomical brain templates, state-of-the-art diffusion tensor and high angular resolution diffusion imaging (HARDI) templates, probabilistic gray matter labels, and probabilistic HARDI connectivity-based multi-layer white matter labels. All resources are in the same space, facilitating multimodal investigations.

  • We have developed a state-of-the-art diffusion tensor template of the young adult brain based on artifact-free Turboprop-DTI data from 72 healthy volunteers.
  • See a comparison of DTI templates

  • We have generated a state-of-the-art HARDI template of the young adult brain by applying super-resolution principles in angular space on artifact-free Turboprop-DTI data.
  • We have produced probabilistic gray matter labels in the space of the IIT Human Brain Atlas by combining multi-atlas segmentation and the popular FreeSurfer labels.
  • We have introduced the concept of multi-layer white matter parcellation providing information about the connectivity of the brain. We constructed multi-layer white matter labels using our whole brain connectome generated from HARDI-based tractography.

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Selected Related Publications

  • Peng H, Orlichenko A, Dawe RJ, Agam G, Zhang S, Arfanakis K. Development of a human brain diffusion tensor template. Neuroimage 2009;46:967-980.
  • Zhang S, Peng H, Dawe RJ, Arfanakis K. Enhanced ICBM diffusion tensor template of the human brain. Neuroimage 2011;54:974-984.
  • Zhang S, Arfanakis K. Role of standardized and study-specific human brain diffusion tensor templates in inter-subject spatial normalization. J Magn Reson Imaging 2013;37:372-381.
  • Zhang S, Arfanakis K. White matter segmentation based on a skeletonized atlas: effects on diffusion tensor imaging studies of regions of interest. J Magn Reson Imaging 2014;40:1189-1198.
  • Varentsova A, Zhang S, Arfanakis K. Development of a high angular resolution diffusion imaging human brain template. Neuroimage 2014;91:177-186.
  • Zhang S, Arfanakis K. Evaluation of standardized and study-specific diffusion tensor imaging templates of the adult human brain: Template characteristics, spatial normalization accuracy, and detection of small inter-group FA differences. Neuroimage 2018;172:40-50.
  • Qi X, Arfanakis K. Regionconnect: Rapidly extracting standardized brain connectivity information in voxel-wise neuroimaging studies. Neuroimage. 2021;225:117462.
DTI template of IIT atlas
IIT connectome
IIT Multi-layer WM labels
Fiber crossings. IIT HARDI template